The Specialized Chemistry Center (SCC) develops probes based on hits uncovered in National Institute of Health (NIH) screening efforts. Three main cores (informatics, synthesis/purification, and administration) comprise the KU SCC, as well as an additional center-driven research project which addresses the question of intracellular target identification for small molecule probes.
Synthesis formats
- Solution-phase
- Solution-phase using solid-phase reagents or scavengers
- Solid-phase
- Serial
- Parallel
- Combinatorial
- Microwave
- SAR expansion
- Hit to lead
- Probe development
- High-throughput analytical-scale RP HPLC/photodiode array UV/HRMS
- High-throughput mass-directed preparative-scale RP HPLC/dual-wavelength UV/LRMS/ELSD
- Medium-throughput, automated, 5mm tube-based 1H and 13C NMR
- Compound formatting available in a variety of formats (vials, plates (96/384)) and solvents
- Virtual compound library enumeration and screening
- In silico property calculation, including ADME, toxicology, and metabolic profiling
- Pharmacophore perception and docking
- Hit clustering and data mining
- 1D/2D/3D QSAR including COMFA, COMBINE
- Target identification and localization using affinity labeling of probe compounds
- Yeast three-hybrid systems as tools for identification of protein targets of probe compounds
- Analog design
- Anti-infectives
- Cancer Cell permeation
- Central nervous system
- Natural products chemistry
- Nuclear receptor system
- Opioids
- Proteases
For equipment, services and collaborative work:
David Hill
Shankel Structural Biology Center
785-854-1668
dhill00@ku.edu
David Hill
Shankel Structural Biology Center
785-854-1668
dhill00@ku.edu
For business related transactions:
Cady Bush
Shankel Structural Biology Center
785-854-5287
cbush@ku.edu
