Access to zebrafish embryos, larvae, and adults for research |
Molecular Probes |
Multicolor flow cytometry |
Immunology |
ELISA |
Immunology |
Cell based assays |
Immunology |
Aseptic cell sorting |
Immunology |
Fluorescence activated cell sorting |
Immunology |
Cytokine quantification |
Immunology |
ELISpot |
Immunology |
Synthesis of fluorescent molecular probes (fluorophores, small molecules, peptides) |
Molecular Probes |
Fluorescence and brightfield imaging of zebrafish |
Molecular Probes |
Fluorescence dissecting microscopy |
Molecular Probes |
Pharmacology/toxicology screening of chemical libraries against zebrafish embryos |
Molecular Probes |
Assay development, fluorescence-based using mammalian cells, zebrafish and C. elegans |
Molecular Probes |
Generation of zebrafish embryos for phenotypic screening and discovery toxicology |
Molecular Probes |
Mammalian cell culture |
Molecular Probes |
Microinjection of model organisms |
Molecular Probes |
Protein digestion |
Analytical Proteomics |
Laboratory automation |
Instrumentation Design |
Label free protein interaction studies |
Protein Production Group |
Biacore label-free binding studies |
Protein Production Group |
Fragment library screening by SPR |
Protein Production Group |
Microarray data generation and analysis |
Genomics Facility |
Real-time PCR |
Genomics Facility |
Target identification and localization using affinity labeling of probe compounds |
Specialized Chemistry Center |
Multispectral in vivo imaging |
Experimental and Preclinical Imaging |
Induction of DNA strand breaks |
Biological Irradiation |
Machine learning and data mining for large scale, multidimensional chemical biology data sets |
Molecular Graphics and Modeling |
Docking and virtual screening of small molecule ligands against protein targets of interest |
Molecular Graphics and Modeling |
Molecular dynamics simulation and modeling of small/macro molecules, proteins, andbiomolecular systems |
Molecular Graphics and Modeling |
Analysis of structure-activity relationships |
Molecular Graphics and Modeling |
Visualization and graphics of biomolecules and biomolecular systems |
Molecular Graphics and Modeling |
Cell survival studies |
Biological Irradiation |
Radiation treatment studies |
Biological Irradiation |
Bone density measurements |
Experimental and Preclinical Imaging |
Preclincial drug efficacy |
Experimental and Preclinical Imaging |
Identification of protein targets of probe compounds using yeast three-hybrid systems |
Specialized Chemistry Center |
Protein structure solution refinement, model building and analysis |
Protein Structure Lab |
Protein crystallization |
Protein Structure Lab |
X-ray diffraction data collection (in-house) |
Protein Production Group |
Synchrotron X-ray diffraction data collection |
Protein Production Group |
Protein characterization and analysis |
Protein Production Group |
Compound identity and purity verification |
Medicinal Chemistry |
Compound reaction sequences (multi-step) |
Medicinal Chemistry |
Compound property predictions |
Medicinal Chemistry |
Protein structure, function and stability prediction, sequence and domain analyses |
Applied Bioinformatics |
Data analysis and mining in proteomics, genomics and chemistry |
Applied Bioinformatics |
Phylogenetic analysis |
Applied Bioinformatics |
Fragment library screening by STD-NMR |
Biomolecular NMR |
NMR data processing, analysis and interpretation |
Biomolecular NMR |
2D-1H-15-HSQC, 2D-1H-13C-HSQC |
Biomolecular NMR |
Structure determination of peptides, proteins, nucleic acids and its complexes |
Biomolecular NMR |
Protein-ligand (drug, peptide, protein) detailed interaction study |
Biomolecular NMR |
Absolute configurations for small molecules |
X-ray Crystallography |
Solid-state structure determinations for microcrystals |
X-ray Crystallography |
Variable-temperature small-molecule and macromolecular/protein diffraction data collection, analysis and interpretation |
X-ray Crystallography |
Phase identification and characterization for crystalline materials |
X-ray Crystallography |
Protein-ligand (drug, peptide, protein) detailed interaction studies in solid-state |
X-ray Crystallography |
Quantitative Powder X-Ray Diffraction (PXRD) data collection and interpretation |
X-ray Crystallography |
Rapid qualitative Powder X-Ray Diffraction (PXRD) data collection and interpretation for microgram samples |
X-ray Crystallography |
Small molecule crystallization |
X-ray Crystallography |
Small molecule (Cambridge) crystal structure database search |
X-ray Crystallography |
Solid-state structure determinations for small organic and inorganic molecules and biological molecules |
X-ray Crystallography |
Thin-film characterization |
X-ray Crystallography |
Protein structure determination |
Protein Structure |
Protein molecular weight determination |
Analytical Proteomics |
Post-translational modification determinations of proteins (i.e. phosphorylation, acetylation) |
Analytical Proteomics |
MALDI-TOF MS analysis of proteins and peptides |
Analytical Proteomics |
LC-MS analysis of peptides |
Analytical Proteomics |
Protein sequence database search |
Analytical Proteomics |
Protein identification |
Mass Spectrometry |
Physicochemical profiling |
BIO Center |
Scanning electron microscopy |
Microscopy and Analytical Imaging |
Light Microscopy, epifluorescence, confocal, and TIRF |
Microscopy and Analytical Imaging |
Live cell imaging |
Microscopy and Analytical Imaging |
Fluorescence activated cell sorting |
Microscopy and Analytical Imaging |
Sample prep for light and electron microscopy |
Microscopy and Analytical Imaging |
Scanning probe microscopy |
Microscopy and Analytical Imaging |
Assay development, analysis and data exploration |
Microscopy and Analytical Imaging |
Transmission electron microscopy |
Microscopy and Analytical Imaging |
Bioavailability and Pharmacokinetics |
BIO Center |
Bio-molecule assays |
BIO Center |
Cell-based assays |
BIO Center |
Prodrug design and synthesis |
BIO Center |
Peptide and small molecule synthesis |
BIO Center |
Hepatic microsomal stability assesment |
BIO Center |
Protein binding and plasma stability |
BIO Center |
Pharmacokinetic (PK) screening |
BIO Center |
Small molecule structure elucidation |
Nuclear Magnetic Resonance |
1D 1H NMR |
Nuclear Magnetic Resonance |
1D 13C NMR |
Nuclear Magnetic Resonance |
Hetronuclear NMR (15N, 19F, 31P, etc.) |
Nuclear Magnetic Resonance |
Quantitative NMR |
Nuclear Magnetic Resonance |
Variable temperature NMR |
Nuclear Magnetic Resonance |
Material characterization in solid state |
Solid State NMR |
Degree of crosslinking in polymers |
Solid State NMR |
HPLC or UPLC/MS or HPLC MS/MS |
Mass Spectrometry |
Electrospray ionization (ESI-MS) |
Mass Spectrometry |
Whole genome sequencing |
Genome Sequencing |
ChIP-seq |
Genome Sequencing |
Methylated DNA sequencing |
Genome Sequencing |
RNA-seq |
Genome Sequencing |
DNA next generation sequencing |
Genome Sequencing |
Genome de novo sequencing or re-sequencing |
Genome Sequencing |
Physical properties and transport of biological fluids |
Microfabrication and Microfluidics |
RNA-seq data analysis |
Genomics and Bioinformatics |
ChIP-seq data analysis |
Genomics and Bioinformatics |
RAD (restriction-site associated DNA) sequencing analysis |
Genomics and Bioinformatics |
Whole genome assembly |
Genomics and Bioinformatics |
Bioanalytical studies (small and large molecules) |
Microfabrication and Microfluidics |
Cell-based assays |
High Throughput Screening |
Enzyme/protein assays |
High Throughput Screening |
Compound screening and profiling |
High Throughput Screening |
Compound synthesis |
Chemical Methodologies and Library Dev. |
Compound library design |
Chemical Methodologies and Library Dev. |