Bioinformatics & Modeling Research

- Consultation on experimental design and research approaches
- Report, grant, and manuscript preparation
- Training and support for students, staff, and faculty on experimental techniques and research methods
Computational Chemistry, Cheminformatics, and Chemical Biology
The Molecular Graphics and Modeling Laboratory provides a number of computational services aimed toward chemical biology and translational science in biomedical research. For example:
- Machine learning and data mining for large scale, multidimensional chemical biology data sets
- Docking and virtual screening of small molecule ligands against protein targets of interest
- Molecular dynamics simulation and modeling of small/macro molecules, proteins, and biomolecular systems
- Analysis of structure-activity relationships
- Visualization and graphics of biomolecules and biomolecular systems
- Custom algorithm/software development along with databases and web applications
Genome Informatics and Systems Biology
The Genomics and Bioinformatics Laboratory serves the needs of investigators engaged in computationally-intensive biomedical research by providing assistance in these areas:
- RNA-seq analysis
- Genome assembly (via a reference sequence or de novo)
- Variant calling and mutation detection
- ChIP-seq analysis
- Restriction-site Associated DNA sequencing (RAD-seq) analysis
Proteomics and Genomics
The Applied Bioinformatics Lab (ABL) is a research-oriented core laboratory providing advanced and comprehensive informatics support to the research community. The ABL staff work on a variety of projects including:
- Data analysis and mining in proteomics, genomics and chemistry
- Systems biology approaches such as pathway, network and interaction analyses; Large scale statistical and machine learning studies
- Protein structure, function and stability prediction, sequence and domain analyses
- Design and implementation of relational databases and software programs
Laboratories
Computational Chemical Biology
Genomics and Bioinformatics
Molecular Graphics and Modeling