Bioinformatics & Modeling Research

The University of Kansas is home to several service laboratories providing computational services in the areas of chemical biology, proteomics, and genome informatics research. These laboratories provide a broad range of services are available for:

Computational Chemistry, Cheminformatics, and Chemical Biology
The Molecular Graphics and Modeling Laboratory provides a number of computational services aimed toward chemical biology and translational science in biomedical research. For example:

• Machine learning and data mining for large scale, multidimensional chemical biology data sets
• Docking and virtual screening of small molecule ligands against protein targets of interest
• Molecular dynamics simulation and modeling of small/macro molecules, proteins, and biomolecular systems
• Analysis of structure-activity relationships
• Visualization and graphics of biomolecules and biomolecular systems
• Custom algorithm/software development along with databases and web applications

Genome Informatics and Systems Biology

The Genomics and Bioinformatics Laboratory serves the needs of investigators engaged in computationally-intensive biomedical research by providing assistance in these areas:

• RNA-seq analysis
• Genome assembly (via a reference sequence or de novo)
• Variant calling and mutation detection
• ChIP-seq analysis
• Restriction-site Associated DNA sequencing (RAD-seq) analysis

Proteomics and Genomics

The Applied Bioinformatics Lab (ABL) is a research-oriented core laboratory providing advanced and comprehensive informatics support to the research community. The ABL staff work on a variety of projects including:

• Data analysis and mining in proteomics, genomics and chemistry
• Systems biology approaches such as pathway, network and interaction analyses; Large scale statistical and machine learning studies
• Protein structure, function and stability prediction, sequence and domain analyses
• Design and implementation of relational databases and software programs

Applied Bioinformatics
Computational Chemical Biology
Genomics and Bioinformatics
Molecular Graphics and Modeling