Todd D. Williams, Ph.D.

Director, Mass Spectrometry and Analytical Proteomics Labs
Primary office:
Malott Hall, room 2010


Todd Williams is the Director of the Mass Spectrometry Laboratory and the Analytical Protemomics Laboratory.  He has had the appointment since starting his career at the university in 1991.

Prior to joining the university, he was a Postdoctoral Associate from 1989 to 1991 at the University of California-Berkeley.

Mr. Williams earned his B.A. in Chemistry/Biology from Middlebury College in 1979.  In 1985 he earned his M.S. in Chemistry and in 1989 he earned his Ph.D. in Chemistry both from the University of Maine. 

In 2013, Todd received the KU ‘Leading Light Award’ given to principal investigators or co-principal investigators on grants of $1M or more and the KU Research Achievement Award.

Select publications

Jiang L, Bechtel MD, Galeva NA, Williams TD, Michaelis EK, Michaelis ML. “Decreases in plasma membrane Ca -ATPase in brain synaptic membrane rafts from aged rats.”J Neurochem. 2012.123:689-699
Sarma D, Hajovsky H, Koen YM, Galeva N, Williams TD, Staudinger JL, Hanzlik RP.” Covalent Modification of Lipids and Proteins in Rat Hepatocytes, and In Vitro, by Thioacetamide Metabolites.” Chem Res Toxicol. 2012 25:1868-77
van Haandel L, Becker ML, Williams TD, Stobaugh JF, Leeder JS.”Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.” Rapid Commun Mass Spectrom. 2012 26:1617
Mozziconacci, O., Williams, T.D., Kerwin, B.A. and Schöneich, Ch. Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and αC-H bonds in insulin: control of selectivity by secondary structure.J. Phys. Chem. B 2008, 112, 15921
Sinha S, Li Y, Williams TD, Topp EM “Protein conformation in amorphous solids by FTIR and by hydrogen/deuterium exchange with mass spectrometry.” Biophys J. 2008 95:5951
C. Bleiholder, S. M. Osburn, T. D. Williams, S. Suhai, M. J. Van Stipdonk, A. Harrison and B. Paizs “Sequence Scrambling Fragmentation Pathways of Protonated Peptides”  J Am Chem Soc, 2008;130:17774
N. A. Galeva, S. W. Esch, T. D. Williams,  L. M. Markille & T.C. Squier “Rapid method for quantifying the extent of methionine oxidation in intact Calmodulin”  J. Am. Soc. Mass Spectrom.  2005 16:1470
R. Welti, W. Li, M. Li, Y. Sang, H. Biesiada, H-E Zhou,  C.B. Rajashekar, T. D. Williams & X. Wang." Profiling Membrane Lipids in Plant Stress Responses: Role of Phospholipase Dα in Freezing-Induced Lipid Changes in Arabidopsis ". J Biol. Chem. 2002 277,31994


Biochemistry & Protein Science

Bioinformatics & Modeling


Materials Characterization

Molecular Structures

Translational Biology

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