Specialized Chemistry Center

The Specialized Chemistry Center (SCC) develops probes based on hits uncovered in National Institute of Health (NIH) screening efforts. Three main cores (informatics, synthesis/purification, and administration) comprise the KU SCC, as well as an additional center-driven research project which addresses the question of intracellular target identification for small molecule probes.

Synthesis formats
  • Solution-phase
  • Solution-phase using solid-phase reagents or scavengers
  • Solid-phase
Synthesis Capabilities
  • Serial
  • Parallel
  • Combinatorial
  • Microwave
  • SAR expansion
  • Hit to lead
  • Probe development
Analysis, Purification and Compound Management
  • High-throughput analytical-scale RP HPLC/photodiode array UV/HRMS
  • High-throughput mass-directed preparative-scale RP HPLC/dual-wavelength UV/LRMS/ELSD
  • Medium-throughput, automated, 5mm tube-based 1H and 13C NMR
  • Compound formatting available in a variety of formats (vials, plates (96/384)) and solvents
Cheminformatics
  • Virtual compound library enumeration and screening
  • In silico property calculation, including ADME, toxicology, and metabolic profiling
  • Pharmacophore perception and docking
  • Hit clustering and data mining
  • 1D/2D/3D QSAR including COMFA, COMBINE
Center-driven projects
  • Target identification and localization using affinity labeling of probe compounds
  • Yeast three-hybrid systems as tools for identification of protein targets of probe compounds
Biological/Medicinal Chemistry Expertise
  • Analog design
  • Anti-infectives
  • ​Cancer Cell permeation
  • Central nervous system
  • Natural products chemistry
  • Nuclear receptor system
  • Opioids
  • ​Proteases
For equipment, services and collaborative work:
David Hill
Shankel Structural Biology Center
785-854-1668
dhill00@ku.edu

For business related transactions:
Cady Bush
Shankel Structural Biology Center
785-854-5287
cbush@ku.edu

LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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