Specialized Chemistry Center

The Specialized Chemistry Center (SCC) develops probes based on hits uncovered in National Institute of Health (NIH) screening efforts. Three main cores (informatics, synthesis/purification, and administration) comprise the KU SCC, as well as an additional center-driven research project which addresses the question of intracellular target identification for small molecule probes.

Synthesis formats
  • Solution-phase
  • Solution-phase using solid-phase reagents or scavengers
  • Solid-phase
Synthesis Capabilities
  • Serial
  • Parallel
  • Combinatorial
  • Microwave
  • SAR expansion
  • Hit to lead
  • Probe development
Analysis, Purification and Compound Management
  • High-throughput analytical-scale RP HPLC/photodiode array UV/HRMS
  • High-throughput mass-directed preparative-scale RP HPLC/dual-wavelength UV/LRMS/ELSD
  • Medium-throughput, automated, 5mm tube-based 1H and 13C NMR
  • Compound formatting available in a variety of formats (vials, plates (96/384)) and solvents
Cheminformatics
  • Virtual compound library enumeration and screening
  • In silico property calculation, including ADME, toxicology, and metabolic profiling
  • Pharmacophore perception and docking
  • Hit clustering and data mining
  • 1D/2D/3D QSAR including COMFA, COMBINE
Center-driven projects
  • Target identification and localization using affinity labeling of probe compounds
  • Yeast three-hybrid systems as tools for identification of protein targets of probe compounds
Biological/Medicinal Chemistry Expertise
  • Analog design
  • Anti-infectives
  • ​Cancer Cell permeation
  • Central nervous system
  • Natural products chemistry
  • Nuclear receptor system
  • Opioids
  • ​Proteases
For equipment, services and collaborative work:
David Hill
Shankel Structural Biology Center
785-854-1668
dhill00@ku.edu

For business related transactions:
Cady Bush
Shankel Structural Biology Center
785-854-5287
cbush@ku.edu

LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

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