Protein Structure X-Ray Lab

The Protein Structure Laboratory provides investigators with state-of-the-art instrumentation, facilities, and expertise for protein crystallization, X-ray data collection, data analysis, and structure solution and refinement from an a la carte menu. Laboratory staff provide advice and consultation, training, access to facilities for experienced crystallographers, and a range of services from crystal growth to full structure solution and refinement.

  • Crystallization of an investigator’s target proteins
  • Collection of complete X-ray diffraction data sets locally and at synchrotron
  • Phase determination (experimentally or through molecular replacement)
  • Model building and refinement of structures deduced from diffraction data
  • High throughput crystallography with protein-ligand complexes
  • Publications and grant applications involving X-ray crystallographic issues
Scott Lovell, Ph.D
Shankel Structural Biology Center, room 1015
785-864-3772
swlovell@ku.edu

LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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