Protein Production Select Publications

2015
Wu X, Lan L, Wilson DM, Marquez RT, Tsao W-C, Gao P, Roy A, Turner B, McDonald P, Tunge JA, Rogers SA, Dixon DA, Aube J, and Xu L. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol 2015

Wu X, Lan L, Wilson DM, Marquez RT, Tsao WC, Gao P, Roy A, Turner BA, McDonald P, Tunge JA, Rogers SA, Dixon DA, Aubé J, Xu L. Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction. ACS Chem Biol. 2015 Jun 19;10(6):1476-84. doi: 10.1021/cb500851u. Epub 2015 Mar 17. PMID:25750985

 

2014
Naik, S., Kumru, O.S., Cullom, M., Telikepalli, S.N., Lindboe, E., Roop, T.L., Joshi, S.B., Amin, D., Gao, P., Middaugh, C.R., Volkin, D.B., Fisher, M.T. (2014) Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Sci. doi: 10.1002/pro.2515. [Epub ahead of print]

Naik S, Kumru OS, Cullom M, Telikepalli SN, Lindboe E, Roop TL, Joshi SB, Amin D, Gao P, Middaugh CR, Volkin DB, Fisher MT. Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio-layer interferometry. Protein Sci. 2014 Oct;23(10):1461-78. doi: 10.1002/pro.2515. Epub 2014 Jul 28. PMID:25043635

2013
Thomas, J.C., O’Hara, J.M., Hu, L., Gao, F.P., Joshi, S.B., Volkin, D.B., Brey, R.N., Fang, J., Karanicolas, J.*, Mantis, N.J., Middaugh, C.R. (2013) Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen. Hum. Vaccin. Immunother. 9(4): 1-9.

2012
​Naik, S., Zhang, N., Gao, F.P., Fisher, M.T.(2012) On the design of broad based screening assays to identify potential pharmacological chaperones of protein misfolding diseases, Curr. Top. Med. Chem.12(22): 2504-22.

Pang, X.Y., Cao, J., Addington, L., Lovell, S., Battaile, K.P., Zhang, N., Rao, J.L., Dennis, E.A., Moise, A.R. (2012) Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. J. Biol. Chem. 287(42):35260-74.


LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
KU Today