Mass Spectrometry Select Publications

2012
Jiang L, Bechtel MD, Galeva NA, Williams TD, Michaelis EK, Michaelis ML. “Decreases in plasma membrane Ca -ATPase in brain synaptic membrane rafts from aged rats.”J Neurochem. 2012.123:689-699

Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP. Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes. Chem Res Toxicol. 2012; 25(5):1145-54. PubMed PMID: 22462724

Sarma D, Hajovsky H, Koen YM, Galeva N, Williams TD, Staudinger JL, Hanzlik RP.” Covalent Modification of Lipids and Proteins in Rat Hepatocytes, and In Vitro, by Thioacetamide Metabolites.” Chem Res Toxicol. 2012 25:1868-7

van Haandel L, Becker ML, Williams TD, Stobaugh JF, Leeder JS.”Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry.” Rapid Commun Mass Spectrom. 2012 26:1617-30.

2002-2008
​Mozziconacci, O., Williams, T.D., Kerwin, B.A. and Schöneich, Ch. Reversible intramolecular hydrogen transfer between protein cysteine thiyl radicals and αC-H bonds in insulin: control of selectivity by secondary structure.J. Phys. Chem. B 2008, 112, 1592

Sinha S, Li Y, Williams TD, Topp EM “Protein conformation in amorphous solids by FTIR and by hydrogen/deuterium exchange with mass spectrometry.” Biophys J. 2008 95:5951

C. Bleiholder, S. M. Osburn, T. D. Williams, S. Suhai, M. J. Van Stipdonk, A. Harrison and B. Paizs “Sequence Scrambling Fragmentation Pathways of Protonated Peptides”  J Am Chem Soc, 2008;130:1777

N. A. Galeva, S. W. Esch, T. D. Williams,  L. M. Markille & T.C. Squier “Rapid method for quantifying the extent of methionine oxidation in intact Calmodulin”  J. Am. Soc. Mass Spectrom.  2005 16:1470

R. Welti, W. Li, M. Li, Y. Sang, H. Biesiada, H-E Zhou,  C.B. Rajashekar, T. D. Williams & X. Wang." Profiling Membrane Lipids in Plant Stress Responses: Role of Phospholipase Dα in Freezing-Induced Lipid Changes in Arabidopsis ". J Biol. Chem. 2002 277,3199


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Biochemistry & Protein Science

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Molecular Structures

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EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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