High Throughput Screening Select Publications

2014
Kenneth R. Peterson, Flávia C. Costa, Halyna Fedosyuk, Renee Y. Neades, Allen M. Chazelle, Lesya Zelenchuk, Andrea H. Fonteles, Parmita Dalal, Anuradha Roy, Rathnam Chaguturu, Biaoru Li, and Betty S. Pace. A Cell-Based High-Throughput Screen for Novel Inducers of Fetal Hemoglobin for Treatment of Sickle Cell Disease, Cooley’s Anemia and β-Thalassemias. Manuscript accepted in PLoS One.

Anuradha Roy (2014).High Throughput Screening Operations at the University of Kansas Combinatorial Chemistry & High Throughput Screening. 2014:17(4), 387-393

Anuradha Roy, Gerald H. Lushington, James McGee & Rathnam Chaguturu. Assay technologies for proteases Chapter 1. pp  3-53. Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents, First Edition. Edited by Hsiu-Chiung Yang, Wu-Kuang Yeh, and James R. McCarthy. © 2014 John Wiley & Sons, Inc. Published 2014 by John Wiley & Sons, Inc.

Diaz FJ, McDonald PR, Chaguturu R, Pinter A (2014) Measuring and statistically testing the size of the effect of a chemical compound on a continuous in-vitro pharmacological response through a new statistical model of response detection limit, Journal of Biopharmaceutical Statistics.  In Press

Wu KC, McDonald PR, Liu JJ, Klaassen CD (2014) Screening of Natural Compounds as Activators of the Keap1-Nrf2 Pathway.  Planta Medica.  80: 97-104. Epub 2013 Dec 5. PMID: 24310212

Anuradha Roy and Rathnam Chaguturu.(2014) Current trends in collaborative drug discovery and strategies to de-risk precompetitive initiatives. Chapter 5, 57-73, Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, First Edition. Edited by Rathnam Chaguturu, 2014 John Wiley & Sons, Inc. Published 2014 by John Wiley & Sons, Inc.

2013
Linda C. Blake, Anuradha Roy, David Neul, Frank J. Schoenen, Jeffrey Aubé, and Emily Scott. (2013) Benzylmorpholine Analogs as Selective Inhibitors of Lung Cytochrome P450 2A13 for the Chemoprevention of Lung Cancer in Tobacco Users. 2013 Jun 12, Epub ahead of print, Pharmaceutical Research. PMID: 23756756, PMC: 3781598

Diaz FJ, McDonald PR, Roy A, Taylor B, Price A, Hall J, Blagg BS, Chaguturu R. Compound ranking based on a new mathematical measure of effectiveness using time course data from cell-based assays.  Comb Chem High Throughput Screen. 16(3):168-179, 2013. PMID: 22934946, PMC: 3655799, NIHMS450310.

Skredenske JM1, Koppolu V, Kolin A, Deng J, Kettle, B, Taylor B, Egan SM. (2013) Identification of a small-molecule inhibitor of bacterial AraC family activators J Biomol Screen. 2013 June18(5):588-98.

P.R. McDonald, A. Roy, and R. Chaguturu. High-Throughput Screening (HTS) in Drug Discovery.  In Encyclopedia of Pharmaceutical Science and Technology, Fourth Edition. Taylor and Francis: New York, Published online: 23 Aug 2013; 1835-1847.

2012
Wu KC, McDonald PR, Liu JJ, Chaguturu R, Klaassen CD (2012) Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway.  PLoS One. 7(10). PMID:23056183, PMC:3466241

Peter R. McDonald, Anuradha Roy and Rathnam Chaguturu (2012) A roadmap for achieving self-sustainability of academic high throughput screening core facilities.  Drug Discovery World, winter, 59-69, 2012.

2011
Peter R. McDonald, Anuradha Roy and Rathnam Chaguturu (2011) The University of Kansas High-Throughput Screening Laboratory. Part II: enabling collaborative drug-discovery partnerships through cutting-edge screening technology. Future Med Chem. Jul;3(9):1101-10. PMID:21806374, PMC3167485, NIHMS316988

Peter R. McDonald, Anuradha Roy and Rathnam Chaguturu (2011) The University of Kansas High-Throughput Screening laboratory. Part I: meeting drug-discovery needs in the heartland of America with entrepreneurial flair. Future Med Chem. 2011 May 3(7):789-95. PMID:21644824, PMC3332045, NIHMS364462

Tai D, Chaguturu R, and Fang J (2011) K-Screen: a free application for high throughput screening data analysis, visualization, and laboratory information management.  Combinatorial Chemistry and High Throughput Screen. Nov: 14 (9) 757-65.  PMID: 216314

Ricardo Macarron, Martyn N. Banks, Dejan Bojanic, David J. Burns, Dragan A. Cirovic, Tina Garyantes, Darren V. S. Green, Robert P. Hertzberg, William P. Janzen, Jeff W. Paslay, Ulrich Schopfer,G. Sitta Sittampalam  (2011) Impact of high-throughput screening in biomedical research, Nature Reviews Drug Discovery 10, 188-195

2010
Anuradha Roy, Peter McDonald and Rathnam Chaguturu (2010) Open Access High Throughput Drug Discovery in the Public Domain: A Mount Everest in the Making. Current Pharmaceutical Biotechnology, Nov 11 (7):764-78. PMID:20809896, PMC: 3716285, NIHMS483192

Chunshan Gui, Amanda Obaidat, Rathnam Chaguturu, and Bruno Hagenbuch (2010) Development of a Cell-Based High-Throughput Assay to Screen for Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3, Current Chemical Genomics; 4:1 8.PMID:2044881 and PMCID: PMC2864424

Chaguturu R (2010) To greater heights, from a solid foundation. Combinatorial Chemistry and High Throughput Screening Jun; 13(5): 375-6 (abstract), PMID:2052874

2009
Anuradha Roy, Byron Taylor, Peter McDonald, Ashleigh Price and Rathnam Chaguturu (2009) Hit-to-Probe to Lead Optimization Strategies: A Biology perspective to conquer the valley of death. Handbook of Drug Screening, Second Edition. Edited by Ramakrishna Seethala and Litao Zang.


LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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