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Examples of Techniques

Experiment/Technique Lab
Access to zebrafish embryos, larvae, and adults for research Molecular Probes
Multicolor flow cytometry Immunology
ELISA Immunology
Cell based assays Immunology
Aseptic cell sorting Immunology
Fluorescence activated cell sorting Immunology
Cytokine quantification Immunology
ELISpot Immunology
Synthesis of fluorescent molecular probes (fluorophores, small molecules, peptides) Molecular Probes
Fluorescence and brightfield imaging of zebrafish Molecular Probes
Fluorescence dissecting microscopy Molecular Probes
Pharmacology/toxicology screening of chemical libraries against zebrafish embryos Molecular Probes
Assay development, fluorescence-based using mammalian cells, zebrafish and C. elegans Molecular Probes
Generation of zebrafish embryos for phenotypic screening and discovery toxicology​ Molecular Probes
Mammalian cell culture Molecular Probes
Microinjection of model organisms Molecular Probes
Protein digestion Analytical Proteomics
Laboratory automation Instrumentation Design
Label free protein interaction studies Protein Production Group
Biacore label-free binding studies Protein Production Group
Fragment library screening by SPR Protein Production Group
Microarray data generation and analysis Genomics Facility
Real-time PCR Genomics Facility
Target identification and localization using affinity labeling of probe compounds Specialized Chemistry Center
Multispectral in vivo imaging Experimental and Preclinical Imaging
Induction of DNA strand breaks Biological Irradiation
Machine learning and data mining for large scale, multidimensional chemical biology data sets Molecular Graphics and Modeling
Docking and virtual screening of small molecule ligands against protein targets of interest Molecular Graphics and Modeling
Molecular dynamics simulation and modeling of small/macro molecules, proteins, andbiomolecular systems Molecular Graphics and Modeling
Analysis of structure-activity relationships Molecular Graphics and Modeling
Visualization and graphics of biomolecules and biomolecular systems Molecular Graphics and Modeling
Cell survival studies Biological Irradiation
Radiation treatment studies Biological Irradiation
Bone density measurements Experimental and Preclinical Imaging
Preclincial drug efficacy Experimental and Preclinical Imaging
Identification of protein targets of probe compounds using yeast three-hybrid systems Specialized Chemistry Center
Protein structure solution refinement, model building and analysis Protein Structure Lab
Protein crystallization Protein Structure Lab
X-ray diffraction data collection (in-house) Protein Production Group
Synchrotron X-ray diffraction data collection Protein Production Group
Protein characterization and analysis Protein Production Group
Compound identity and purity verification Medicinal Chemistry
Compound reaction sequences (multi-step) Medicinal Chemistry
Compound property predictions Medicinal Chemistry
Protein structure, function and stability prediction, sequence and domain analyses Applied Bioinformatics
Data analysis and mining in proteomics, genomics and chemistry Applied Bioinformatics
Phylogenetic analysis Applied Bioinformatics
Fragment library screening by STD-NMR Biomolecular NMR
NMR data processing, analysis and interpretation Biomolecular NMR
2D-1H-15-HSQC, 2D-1H-13C-HSQC Biomolecular NMR
Structure determination of peptides, proteins, nucleic acids and its complexes Biomolecular NMR
Protein-ligand (drug, peptide, protein) detailed interaction study Biomolecular NMR
Absolute configurations for small molecules X-ray Crystallography
Solid-state structure determinations for microcrystals X-ray Crystallography
Variable-temperature small-molecule and macromolecular/protein diffraction data collection, analysis and interpretation X-ray Crystallography
Phase identification and characterization for crystalline materials X-ray Crystallography
Protein-ligand (drug, peptide, protein) detailed interaction studies in solid-state X-ray Crystallography
Quantitative Powder X-Ray Diffraction (PXRD) data collection and interpretation X-ray Crystallography
Rapid qualitative Powder X-Ray Diffraction (PXRD) data collection and interpretation for microgram samples X-ray Crystallography
Small molecule crystallization X-ray Crystallography
Small molecule (Cambridge) crystal structure database search X-ray Crystallography
Solid-state structure determinations for small organic and inorganic molecules and biological molecules X-ray Crystallography
Thin-film characterization X-ray Crystallography
Protein structure determination Protein Structure
Protein molecular weight determination Analytical Proteomics
Post-translational modification determinations of proteins (i.e. phosphorylation, acetylation) Analytical Proteomics
MALDI-TOF MS analysis of proteins and peptides Analytical Proteomics
LC-MS analysis of peptides Analytical Proteomics
Protein sequence database search Analytical Proteomics
Protein identification Mass Spectrometry
Physicochemical profiling BIO Center
Scanning electron microscopy Microscopy and Analytical Imaging
Light Microscopy, epifluorescence, confocal, and TIRF Microscopy and Analytical Imaging
Live cell imaging Microscopy and Analytical Imaging
Fluorescence activated cell sorting Microscopy and Analytical Imaging
Sample prep for light and electron microscopy Microscopy and Analytical Imaging
Scanning probe microscopy Microscopy and Analytical Imaging
Assay development, analysis and data exploration Microscopy and Analytical Imaging
Transmission electron microscopy Microscopy and Analytical Imaging
Bioavailability and Pharmacokinetics BIO Center
Bio-molecule assays BIO Center
Cell-based assays BIO Center
Prodrug design and synthesis BIO Center
Peptide and small molecule synthesis BIO Center
Hepatic microsomal stability assesment BIO Center
Protein binding and plasma stability BIO Center
Pharmacokinetic (PK) screening BIO Center
Small molecule structure elucidation Nuclear Magnetic Resonance
1D 1H NMR Nuclear Magnetic Resonance
1D 13C NMR Nuclear Magnetic Resonance
Hetronuclear NMR (15N, 19F, 31P, etc.) Nuclear Magnetic Resonance
Quantitative NMR Nuclear Magnetic Resonance
Variable temperature NMR  Nuclear Magnetic Resonance
Material characterization in solid state Solid State NMR
Degree of crosslinking in polymers Solid State NMR
HPLC or UPLC/MS or HPLC MS/MS Mass Spectrometry
Electrospray ionization (ESI-MS) Mass Spectrometry
Whole genome sequencing Genome Sequencing
ChIP-seq Genome Sequencing
Methylated DNA sequencing Genome Sequencing
RNA-seq Genome Sequencing
DNA next generation sequencing Genome Sequencing
Genome de novo sequencing or re-sequencing Genome Sequencing
Physical properties and transport of biological fluids Microfabrication and Microfluidics
RNA-seq data analysis Genomics and Bioinformatics
ChIP-seq data analysis Genomics and Bioinformatics
RAD (restriction-site associated DNA) sequencing analysis Genomics and Bioinformatics
Whole genome assembly Genomics and Bioinformatics
Bioanalytical studies (small and large molecules) Microfabrication and Microfluidics
Cell-based assays High Throughput Screening
Enzyme/protein assays High Throughput Screening
Compound screening and profiling High Throughput Screening
Compound synthesis Chemical Methodologies and Library Dev.
Compound library design Chemical Methodologies and Library Dev.


Biochemistry & Protein Science

Bioinformatics & Modeling


Materials Characterization

Molecular Structures

Translational Biology

Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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