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Eduardo Rosa-Molinar, Ph.D

Director, Microscopy Analytical Imaging Resource Core Laboratory (MAI)
Professor, Department of Pharmacology and Toxicology, School of Pharmacy
Primary office:
785-864-3091
Haworth Hall, room 1036
Second office:
785-864-4380
Haworth Hall, room 1043



Eduardo Rosa-Molinar, Ph.D. is the Director of the Microscopy and Analytical Imaging Resource Core Laboratory (http://mai.ku.edu/eduardo-rosa-molinar-phd), Professor of Pharmacology and Toxicology and Neuroscience Graduate Program (http://pharmtox.ku.edu/all-faculty; http://neuroscience.ku.edu/faculty-members), and Professor of Anatomy and Cell Biology (http://www.kumc.edu/school-of-medicine/anatomy-and-cell-biology/secondary-appointment-faculty.html) at the University of Kansas and the University of Kansas Medical Center respectively.  He is also a Whitman Scientist at the Whitman Center, Marine Biological Laboratory (http://www.mbl.edu/research/mbl-scientists/) and Course Director of the Immunohistochemistry and Microscopy, a special topic course taught at the Marine Biological Laboratory, Woods Hole, MA (http://www.mbl.edu/education/special-topics-courses/immunohistochemistry-and-microscopy-ihcm/).  Until June 2015, he was a tenured Professor of Integrative Anatomy and Neurobiology, University of Puerto Rico-Rio Piedras, San Juan Puerto Rico.

His research focuses on “neural microcircuits", a specific pattern of interconnections between neurons and synapses within a specific region of the central nervous system (i.e., spinal cord); he images and studies the three-dimensional (3-D) nano-scale architecture of “mixed synapses”, a poorly studied synapse that combines the features of both chemical and electrical synapses (i.e., gap junction).  To this end, he develops quantitative immuno-correlative photon- and electron-based imaging technologies required to image and analyze in 3-D the nano-scale membrane organization of mixed synapses’ pre-and post-synaptic membrane proteins.  The way in which the 3-D the nano-scale membrane organization of mixed synapses’ pre-and post-synaptic membrane proteins present therein, structural and topographical information is critical to guide structure-based drug design and discovery.

Selected Publications

Names that are underlined indicate current and former laboratory members, including technicians undergraduate and graduate students, and post-doctoral fellows.

Peer-Reviewed Papers and Extended Abstracts (submitted/in revision)

  1. Martínez-Rivera, N., Serrano-Vélez, J. L., Torres-Vázquez, I. I., and Rosa-Molinar, E.  Superficial neuromasts as proprioceptors underlying a fast innate behavior.  "Biodiversity of sensory systems in aquatic vertebrates", in Front.  Ecol. and Evol. (submitted)
  2. Serrano‐Velez, J. L., Santiago-Robles, C. M., Rodriguez‐Alvarado, M., Martinez‐Rivera, N.Torres‐Vazquez, I. I., and Rosa‐Molinar, E. Dissection and analytics of a neural circuit: From neurons‐ to‐dendrites‐to‐connexin35‐containing gap junction’s puncta‐to-connectivity.  “Connexin- and pannexin-mediated pathways in homeostatic and pathological central nervous system”, in Front. Cell. Neurosci. (submitted)
  3. Garcia-Lebron, R., Koutis, I., Torres-Vazquez, I. I., Martinez‐Rivera, N., Serrano-Velez, J. L., and Rosa-Molinar, E. Automating Cellular Connectomics: Spectral algorithms permit three-dimensional segmentation of neurons. “Integrating brain anatomical, functional and effective connectivity” in Front. Neurosci. (submitted)

Peer-Reviewed Book (forthcoming)

  1. Rosa-Molinar, E., Fraser, S. F., and Macagno, E. R. [guest editors] (commissioned “stand-alone” mini-book in a new imaging series published by Springer). SpringerBriefs in Biological Imaging Series: Correlative Three-dimensional Microscopy of Extended Tissue Volumes, D. J. Taatjes (series ed.), Springer, New York, NY; 3rd edition.

Peer-Reviewed Papers (published)

  1. Hewitt, S. M., Baskin, D. G., Frevert, C. W., Stahl, W. L., and Rosa-Molinar, E. (2014). Controls for immunohistochemistry: Controls for Immunohistochemistry: The Histochemical Society's Standards of Practice for Validation of Immunohistochemical Assays.  J. Histochem. Cytochem. Jul 14. pii: 0022155414545224. [Epub ahead of print] PMID: 25023613.
  2. Serrano-Velez, J. L.Rodriguez-Alvarado M.Torres-Vazquez I. I., Fraser, S. E., Yasumura, T., Vanderpool, K. G., Rash, J. E. and Rosa-Molinar, E. (2014). Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons. Front. Neural Circuits 8 (66):1-16; doi: 10.3389/fncir.2014.0006.

Selected Grants

ACTIVE

R43 GM 115042 (Rosa-Molinar) (Consortium PI) 10/01/15-09/30/16 0.3 calendar month
NIH/NIGMS $251,977 (direct)
Luminescent Metal Complex Probes for Correlative Microscopy

R43 MH-106245 (Rosa-Molinar) (Consortium PI) 08/01/15-07/31/16 NCE 0.3 calendar month
NIH/NIMH $225,000 (direct)
Conductive Metalllography for Serial Section Electron Microscopy at Nanometer Resolution

HRD-1137725 (Rosa-Molinar) (Consortium PI) 09/01/11-08/31/17 0.6 calendar month
NSF $4,985,003.00 (direct)
Puerto Rico Center for Environmental Neuroscience

IOS-1557754 (Gilly, Rosenthal, Kier, Rosa-Molinar) 09/01/16-08/31/19 0.6 calendar month

NSF $450,000 (direct)

Structural and Functional Connectivity of Squid Chromatophores

5 T36 GM 008637-21 (Rosa-Molinar) 09/30/96 -08/31/17 0.5 calendar month
NIH/NIGMS $834,383 (direct; NCE)/No salary support requested
Leadership, Excellence and Development of Diversity in Research

PENDING

IPERT R25 (new application) (Rosa-Molinar) 09/01/16-08/31/17 0.5 calendar month
NIH/NIGMS $600,001 (direct)/No salary support requested
Diversity Resources for Enrichment, Access and Mentoring 2

R43 GM (new application) (Joshi, Rosa-Molinar) 04/05/17-03/31/18 1.2 calendar month
NIH/NIGMS $244,325 (direct)
Peroxidase Mimics for Electron and Correlative Microscopy

R01 GM (new application) (Rosa-Molinar) 09/01/17-08/31/23 2.5 calendar months
NIH/NIGMS $1,821,355 (direct)
Developing a Toolkit for Immuno-correlative Light and Electron Microscopy

R43 GM (new application) (Joshi and Rosa-Molinar) 10/05/17- 09/31/18 1.2 calendar month
NIH/NIGMS $249,539.67 (direct)
Carbon “dots” for Correlative Microscopy


LINKS TO LAB WEBSITES

Biochemistry & Protein Science

Bioinformatics & Modeling

Cross-Disciplinary

Materials Characterization

Molecular Structures

Translational Biology

EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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