CMLD Select Publications

For a complete list of publications, go to the CMLD website.

2014
Perchellet, J-P. H; Perchellet, E.M.; Singh, C.R.; Monnett, M.T.; Studer, E.R.; Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G.H.; Santini, C.; Buszek, K.R.  Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro.  Anticancer Research,2014, 34, 1643-1656.

2013
Kumar, S.; Thornton, P.D.; Painter, T.O.; Jain, P.; Downard, J.; Douglas, J.T.; Santini, C. Synthesis of a Family of Spirocyclic Scaffolds; Building Blocks for the Exploration of Chemical Space. J. Org. Chem. 2013, web date June 12, 2013.

Painter, T.P.; Kaszas, K.; Gross, J.; Douglas, J.T.; Day, V.W.; Iadarola, M.J.; Santini, C. Constrained TRPV1 agonists synthesized via silver-mediated intramolecular azo-methine ylide cycloaddition of α-iminoamides.  Bioorg. & Med. Chem. Lttrs, 2014, 24, 963-968.

Painter, T.O.; Bunn, J.R.; Schoenen, F.J.; Douglas, J.T.; Day, V.W.; Santini, C. Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from N-Substituted Homopropargyl Alcohols. J. Org. Chem. 2013, 78(8), 3720-3730. 

Dubrovskiy, A.V.; Jain, P.; Shi, F.; Lushington, G.H.; Santini, C.; Porubsky, P.; Larock, R.C. Solution-Phase Synthesis of a Diverse Library of Benzisoxazoles Utilizing the [3 + 2] Cycloaddition of in Situ-Generated Nitrile Oxides and Arynes. ACS Comb. Sci. 2013, 15(4), 193-201. 

2012

Fenster, E.; Hill, D.; Reiser, O.; Aubé, J. Automated Three-Component Synthesis of a Library of Lactams. Beilstein J. Org. Chem. 2012, 8, 1804-1813.

Loh, J.K.; Yoon, S.Y.; Samarakoon, T.B.; Rolfe, A.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Hanson, P. R. Exploring Diversity via a Modular Reaction Pairing Strategy. Beilstein J. Org. Chem. 2012, 8, 1293-1302. 

Wrobel, M.; Aubé, J.; König, B. Parallel Solid Phase Synthesis of Diaryltriazoles. Beilstein J. Org. Chem. 2012, 8, 1027-1036. Part of the thematic series "Recent developments in chemical diversity".

Zang, Q.; Zhou, A.; Javed, S.; Maity, P.K.; Knudtson, C.A.; Bi, D.; Hastings, J.J.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-pot Sulfonylation/Thia-Michael Protocol. Heterocycles 2012, 86, 1661-1674. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi. 

Zang, Q.; Javed, S.; Zhou, A.; Knudtson, C.A.; Bi, D.; Basha, F.Z.; Hanson, P.R. Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams. Heterocycles 2012 , 86, 1675-1688. Special Issue Honoring Nobel Laureate Professor Ei-ichi Negishi.

Chattopadhyay, K.; Fenster, E.; Grenning, A.J.; Tunge, J.A. Palladium-catalyzed substitution of (coumarinyl) methyl-acetates with C-, N- and S-nucleophiles. Beilstein J. Org. Chem. 2012, 8, 1200-1207.

Faisal, S.; Ullah, F.; Maity, P.K.; Rolfe, A.; Samarakoon, T.B.; Porubsky, P.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Facile (Triazolyl) methylation of MACOS-derived Benzofused Sultams Utilizing ROMP-derived OTP Reagents. ACS Combi. Sci. 2012, 14(4), 268-272. 

Zang, Q.; Javed, S.; Porubsky, P.; Ullah, F.; Neuenswander, B.; Lushington, G.H.; Basha, F.Z.; Organ, M.G.; Hanson, P.R. Synthesis of a unique isoindoline/tetrahydroisoquinoline-based tricyclic sultam library utilizing a Heck-aza-Michael strategy ACS Combi. Sci. 2012, 14(3), 211-217. 

Rogness, D.C.; Markina, N.A.; Waldo, J.P.; Larock, R.C. Synthesis of Pyrido[1,2-?]indole Malonates and Amines through Aryne Annulation. Comb. Chem. High Throughput Screening 2012, 77, 2743-2755.

Fang, Y.; Larock, R.C.; Nucleophilic Addition of 2,3-Pyridyne and Synthesis of Benzonaphthyridinones. Tetrahedron 2012, 68, 2819-2826.

Lu, C.; Larock, R. C.; Synthesis of 9-Substituted Xanthenes by the Condensation of Arynes with ortho-Hydroxychalcones. Tetrahedron Lett. 2012, 53, 2202-2205.

Lu, C.; Larock, R. C.; Synthesis of Benzisoxazolines by the Coupling of Arynes with Nitrones. J. Org. Chem. 2012, 77, 2279-2284.

Markina, N.A.; Dubrovskiy, A.V.; Larock, R.C.; One-pot Synthesis of 1-Alkyl-1H-indazoles from 1,1-Dialkylhydrazones via Aryne Annulation. Org. Biomol. Chem. 2012, 10, 2409-2412.

Perchellet, J.-P. H.; Waters, A. M.; Perchellet, E. M.; Thornton, P. D.; Brown, N.; Hill, D.; Neuenswander, B.; Lushington, G. H.; Santini, C.; Chandrasoma, N.; Buszek, K. R.; Antitumor Effects of Synthetic 6,7-Annulated-4-Substituted Indole Compounds in L1210 Leukemic Cells in Vitro. Anticancer Res. 2012 , 32, 4671-4684.

Brown, N.; Buszek, K. R.; Regioselectivity of Diels-Alder Reactions Between 6,7-Dehydrobenzofuran and 2-Substituted Furans. Tetrahedron Lett. 2012, 53, 4022-4025.

 


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