Biomolecular NMR Select Publications

2012
​Rosslyn, G., Fabien, K., Sorgen, P.L. (2012)1H, 13C, and 15N backbone resonance assignments of the connexin43 carboxyl terminal domain attached to the 4th transmembrane domain in detergent micelles. Biomol NMR Assign. 2012, October 13, 2012. [Epub ahead of print]

Sarma, A.V., Anbanandam, A., Kelm, A., Mehra-Chaudhary, R., Wei, Y., Qin, P., Lee, Y., Berjanskii, M.V., Mick, J.A., Beamer, L.J., Van Doren, S.R. (2012) Solution NMR of a 463-residue phosphohexomutase: domain 4 mobility, substates, and phosphoryl transfer defect. Biochemistry 51(3):807-19.

2011
Fernando Estrada, D., De Guzman, R. N. (2011) Structural Characterization of the Crimean-Congo Hemorrhagic Fever Virus Gn Tail Provides Insight into Virus Assembly. J. Biol. Chem. 286:21678-21686.

Fernando Estrada, D., Conner, M.,  St. Jeor, S. C.,  De Guzman, R. N. (2011) The structure of the hantavirus zinc finger domain is conserved and represents the only natively folded region of the Gn cytoplasmic tail. Front. Microbio. 2, 251, 1-8.

Chatterjee, S., Zhong, D., Nordhues, BA., Battile, KP.,Lovell, S., De Guzman, RN. (2011) The crystal structures of the Salmonella type III secretion system tip protein SipD in complex with deoxycholate and chenodeoxycholate. Protein Sci. 20:75-86.

Takahashi, D., Kim, Y., Chang, K.O., Anbanandam, A., Prakash, O. (2011) Backbone and side-chain (1)H, (15)N, and (13)C resonance assignments of Norwalk virus protease. Biomol. NMR Assign. Jun 8.

Day, T.P., Sil, D., Shukla, N.M., Anbanandam, A., Day, V.W., David, S.A. (2011) Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Mol. Pharm. 8(1):297-301.

2008-2009
Williams, A.S., Lovell, S., Anbanandam, A., El-Chami, R., Bann, J.G. (2009) Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH. Protein Sci. 18: 2277-2286.

Wang Y, Zhang L, Picking WL, Picking WD, De Guzman RN. (2008) Structural dissection of the extracellular moieties of the type III secretion apparatus. Mol. BioSyst. 4, 1176-80.

Wang Y, Boudreaux DM, Estrada DF, Egan CW, St. Jeor SC, De Guzman RN. (2008) NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein. J. Biol. Chem. 283, 28297-304. PMID: 18687679.

Nonoyama, A., Laurence, J.S., Garriques, L., Qi, H., Le, T., and Middaugh, C.R. (2008) A biophysical characterization of AC137 and evaluation of the empirical phase diagram using a peptide model. J. Pharm. Sci., 97:2552-67.

Martin, A., David. V., Laurence, J.S., Schwarz, P.M., Lafer, E.M., Hedge, A.M., and Rowe, P.S. (2008) ³Degradation of MEPE, DMP1 & release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP², Endocrinology 149: 1757-1772.

Skinner, A.L. and Laurence, J.S. (2008) High-field Solution NMR Spectroscopy as a tool for Assessing Protein Interactions with Small Molecule Ligands², J. Pharm. Sci. 97: 4670-4695.

Ciaccio, N.A., Moreno, M.L., Bauer, R.L. and Laurence, J.S. (2008) High-Yield Expression in E. coli and Refolding of the bZIP Domain of Activating Transcription Factor 5. Protein Expr. Purif. 62, 235-243.


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EVENTS
Ability to set up 24 NMR experiments at one time and eliminate periodic user intervention
Screen up to 100,000 compounds in two days for endpoint assays
Next-generation genome sequencing
Near-infrared and bioluminescence imaging instrumentation to track gene of interest and/or tumor growth
Expertise in the design and stability of various pharmaceutical dosage forms
More than 40 computational chemistry software programs and databases
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